In 2011, Lowe appeared on The Oprah Winfrey Show and stated that he left the show because he did not feel he was being respected, when the other lead characters received a raise and he did not. In 2005, he starred as Lieutenant Daniel Kaffee in a London West End production of Sorkin's play A Few Good Men, the first time the two had worked together since The West Wing.After leaving the show, Lowe was the star and executive producer of a failed NBC drama, The Lyon's Den (2003). Although Lowe had expressed unhappiness about his decreased role on that show at the time of his departure, he has now repeatedly said that any animosity between them is over and that he was pleased to be working once more with Sorkin, whose talents as a writer Lowe highly regards. Derek Shepherd of Grey's Anatomy, which eventually went to Patrick Dempsey.His breakthrough role was his big screen debut in 1983, when he and Emilio Estevez were cast in Francis Ford Coppola's The Outsiders. Elmo's Fire, making them the two more prominent actors from the group known as the Brat Pack. followed, with Demi Moore (who had starred alongside Lowe in St. He then received his second Golden Globe Award nomination for Best Supporting Actor for his role as the mentally disabled Rory in Square Dance (1987).Lowe played the role of Sodapop Curtis, the brother of the main character Ponyboy Curtis (C. In August 1987 he performed on stage, playing Baron Tusenbach in Chekov's The Three Sisters at The Williamstown Theatre Festival. He came to prominence as a teen idol in the 1980s, appearing in teen and young adult film roles in The Outsiders (1983), Oxford Blues (1984), St. Lowe appeared as Robert Mc Callister on the ABC television drama Brothers & Sisters (2006–2010), followed by a four-year run as Chris Traeger on the NBC sitcom Parks and Recreation (2010–14), for which he was critically acclaimed. Ethan Willis on the CBS medical drama Code Black (2015–) and appears with his two sons, Matthew and John Owen, in the A&E reality series The Lowe Files (2017–).
Lowe and series creator Aaron Sorkin soon found themselves at odds over the network's meddling with the show, most notably the network demanding changes in the Sam Seaborn character.
Lowe was drawn to the role because of his personal love of politics, and his longstanding personal relationship with Martin Sheen, who was cast as President Bartlet.
When the show premiered, Seaborn was considered the lead, and the pilot centered on the character.
Lowe is currently teaming up with 44 Blue to produce a reality series entitled Potomac Fever about young adults living in Washington, D. In 2011, Lowe guest starred in a recurring role on Showtime's comedy Californication.
Lowe featured as the troubled but in-demand actor Eddie Nero – a character based upon "about ten people", according to Lowe During his promotional tour for Stories I Only Tell My Friends, Lowe told Australian radio show The Kyle & Jackie O Show that during his five-day press visit to Australia in 1990, he was so badly affected by the overuse of painkillers that the only two things he remembers from the trip were being at the Sydney Zoo and getting a tattoo, although he states in his book that he does not remember getting the tattoo.